Toxicology
The functional screening of substances with neuronal networks provides important indications about toxicology and safety pharmacology. Unexpected neurophysiological side effects can be discovered early through
NeuroProof technology. Thus, important cost-saving indications can be furnished early in the development of pharmaceuticals.
IC50 test - Assessment of the effective domain
The effective domain of substances can be shown by dose-effect curves. When explicit indications of the substances' site of action are present, this information can be further specified using optimised tissue-specific cultures.
The Hill-coefficient as important parameter for Safety Pharmacology
The run of the dose-effect curve shows if multiple mechanisms of action are exist. The slope of the dose-effect curves which is called Hill-coefficient provides indications about how critical an incorrect dose could be in treatment.
Neuronal networks as broadband sensor
Unknown new effects can also be detected with the help of neuronal networks. This is mostly impossible with other technologies as these presume fundamental knowledge of the effect mechanisms.
Acute vs. Chronic Toxicology
Besides acute toxic effects,
NeuroProof technology can also describe chronic effects both in functional neurotoxicology and in cytotoxicology.
Discovery of combination effects
Critical combination effects of substances e.g. drug interactions, i.e. with alcohol or barbiturates, can be recognised and quantified with the help of isobolography.
