Clarification of mechanisms of actions for neuro-active substances
NeuroProof technology allows an accelerated clarification of effect mechanism of neuro-active drugs. Pharmalogical tests (mechanisms test for determining the place of action, tissue-specificity test, KD-test), toxicity tests (EC50-acute, EC50-chronic) are offered as well as tests which aim at specific disease models. For the latter, electrophysiological parameters are collected multi-parametrically by default. The specifically influenced parameters are combined to a more significant analogous-model test.
The following qualitative and quantitative statements about the effect of the test substances on the network activity can be made:
- Acute and chronic influence
- Reversible and irreversible behaviour
- Inhibitory or agitating effect
- Activity regulating or activity modulating effect
- Specific or unspecific effect on receptors
- Concentration sphere of action (EC50-curves)
- Tissue-specific behaviour (frontal cortex, spinal cord, ...)
- Reproducibility of the effects
Procedural diagram of the clarification of the effect mechanisms
The standard test provides information about physiologically relevant effect mechanisms. Using information obtained in the first tests, precise information about the effect mechanism of a substance can be obtained through specific blockade experiments by means of the first information.
